Published Date: | Updated Date:

Manuka Honey for IBD: What the Research Says

by Amy Fennell, Manuka Honey Research Lead
Manuka honey benefits for IBD symptoms

 Key Takeaways

  • Manuka honey for IBD is supported by emerging research, with studies showing its bioactive compounds may help support inflammation balance in the gut.

  • MGO strength matters, with higher MGO Manuka honey containing greater concentrations of bioactive compounds, including phenols linked to gut health support.

  • While promising, current evidence is largely preclinical, meaning Manuka honey should be used as a complementary dietary addition alongside medical guidance.


Manuka honey for IBD is an emerging area of interest for those seeking natural ways to support gut health alongside conventional care. Sourced from the Leptospermum plant native to Australia and New Zealand, Manuka honey is uniquely rich in bioactive compounds that have been widely studied for their role in inflammation and digestive health.

Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is a chronic autoimmune condition with no current cure. Management typically focuses on reducing inflammation and supporting gut function through medical treatment and diet.

Medical-grade Manuka honey has been explored in peer-reviewed research for its role in gut health, immune support, and inflammation modulation (1). Its strength is measured by methylglyoxal (MGO), a naturally occurring compound that indicates concentration and potency. The higher the MGO rating, the greater the strength, bioactivity, and value of the honey.

What is IBD and why is inflammation the key target?

Inflammatory bowel disease is characterised by chronic inflammation of the gastrointestinal tract and includes:

  • Crohn’s disease – inflammation that can affect any part of the digestive tract

  • Ulcerative colitis – inflammation limited to the colon and rectum

Both conditions involve an overactive immune response that drives persistent inflammation. For this reason, reducing inflammatory activity remains central to both medical and dietary management strategies.

Woman with hands on stomach in a heart shape symbolising IBD symptoms

What makes Manuka honey unique?

Manuka honey stands apart from regular honey due to its naturally occurring bioactive profile. Unlike standard honey, it contains a unique combination of compounds that contribute to its biological activity.

These include:

  • Methylglyoxal (MGO) - the key marker used to measure Manuka honey strength

  • Polyphenols - plant-based antioxidants that help regulate oxidative stress

  • Lepteridine (3,6,7-Trimethyllumazine) - a Manuka-specific compound currently being studied for its role in inflammatory pathways

Laboratory research has shown that Lepteridine may influence enzymes such as matrix metalloproteinase-9 (MMP-9), which are associated with inflammatory processes in the gastrointestinal tract (2). Early-stage findings suggest this compound may remain stable through digestion, allowing interaction within the gut environment.

What does the research say about Manuka honey for IBD?

Research into Manuka honey for IBD is still developing, with most studies conducted in controlled laboratory and animal models.

Honey vs prednisolone study

In an induced colitis model, honey was administered alongside prednisolone and saline. Results showed that honey supported a reduction in inflammatory markers within the study model conditions (1).

Dose-dependent response study

A separate study assessing different doses of Manuka honey found that both low and high doses contributed to reductions in colonic inflammation over a 14-day period (3).

Lepteridine and inflammatory pathways study

In vitro research has demonstrated that Lepteridine may influence MMP-9 activity, an enzyme linked to tissue inflammation and mucosal degradation in gastrointestinal conditions (2).

While these findings are promising, it is important to note that human clinical evidence remains limited. A recent feasibility study is exploring Manuka honey in gastrointestinal conditions, with further outcomes still emerging.

Does Manuka honey help with Crohn’s disease specifically?

Current research on Manuka honey for IBD has largely focused on ulcerative colitis models. However, the underlying mechanisms - including modulation of inflammatory pathways and antioxidant activity - are relevant to both Crohn’s disease and ulcerative colitis.

At this stage, condition-specific human trials are still required. Individuals with Crohn’s disease should consult their healthcare provider before introducing Manuka honey into their diet.

How to incorporate Manuka honey into your diet

When considering Manuka honey for IBD, a measured and personalised approach is essential.

Choose the right MGO strength

Higher MGO ratings indicate greater concentration of bioactive compounds. Many individuals exploring gut health support choose MGO 880+ and above, depending on their needs.

Start gradually

Begin with small amounts, such as half a teaspoon daily, and monitor tolerance.

Consider dietary context

For those following a low FODMAP approach, Manuka honey may not be suitable during active flare-ups due to its natural fructose content. It is often better introduced during periods of remission.

Consult your healthcare provider

Manuka honey should be used as a complementary dietary addition, not a replacement for prescribed treatment.

Practical ways to use Manuka honey for IBD support infographics

Understanding MGO strength when choosing Manuka honey 

When selecting Manuka honey for IBD, MGO strength is one of the most important factors to consider.

MGO (methylglyoxal) is the naturally occurring compound responsible for the honey’s bioactivity. As the MGO rating increases, so too does the concentration, potency, and overall value of the honey.

For a detailed breakdown, refer to the Manuka Honey Strength Chart.

Manuka Honey MGO Strength and Suggested Uses
MGO Strength Grade Suggested Uses
MGO 30+ to 290+ Everyday Strength Table Grade Wellbeing, Immunity
MGO 300+ to 490+ Medicinal Strength Therapeutic Grade Sore throats, coughs, colds & flu, oral care
MGO 500+ to 990+ High Medicinal Strength Therapeutic Grade+
MGO 1000+ to 1900+ (Rare) Superior Strength Medical Grade Burns, wounds, ulcers, infections, gut health
MGO 2200+ (Limited Edition) Ultimate Strength Medical Grade+

 

Choosing the right strength depends on your individual needs, tolerance, and how you plan to incorporate Manuka honey into your routine.

The Role of Manuka Honey for IBD in Gut Health Support

Manuka honey for IBD represents a promising area of nutritional research, supported by its unique composition of MGO, polyphenols, and emerging compounds such as Lepteridine.

While current evidence is largely preclinical, early findings suggest potential for supporting gut health and inflammation balance as part of a broader management strategy. As research evolves, Manuka honey continues to gain recognition as a functional food grounded in both tradition and science.

As Dr Peter Brooks, Senior Chemist and Researcher at the University of the Sunshine Coast, explains:

“Manuka honeys have the unique ability, with the phenols present, to have an anti-inflammatory action on the gut. The higher the MGO rating, the higher the phenolic content, which also give anti-inflammatory actions.” (4)

While current evidence is largely preclinical, early findings suggest potential for supporting gut health and inflammation balance as part of a broader management strategy.

As scientific understanding deepens, Manuka honey continues to gain recognition as a functional food grounded in both tradition and ongoing research. For those seeking high-quality, high-MGO options, explore Biosota’s medicinal Manuka honey range.

 

FAQs

Is Manuka honey for IBD supported by research?

Early-stage studies suggest Manuka honey may support inflammation balance in IBD models. Human clinical trials are ongoing.

What MGO level is best for Manuka honey for IBD?

MGO 400+ and above is commonly chosen for higher bioactivity, with stronger grades offering greater concentration of key compounds.

Can Manuka honey be used during an IBD flare-up?

This depends on individual tolerance and dietary protocols. Those following low FODMAP may need to avoid it during flare-ups.

 

References

  1. Bilsel, Y., Bugra, D., Yamaner, S., Bulut, T., Cevikbas, U., & Turkoglu, U. (2002). Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation. Digestive Surgery, 19(4), 306–312.
    Link: https://doi.org/10.1159/000064580
  2. Lin, B., Nair, S., Fellner, D. M. J., Nasef, N. A., Singh, H., Negron, L., Goldstone, D. C., Brimble, M. A., Gerrard, J. A., Domigan, L., Evans, J. C., Stephens, J. M., Merry, T. L., & Loomes, K. M. (2023). The Leptospermum scoparium (Mānuka)-Specific Nectar and Honey Compound 3,6,7-Trimethyllumazine (Lepteridine<sup>TM</sup>) That Inhibits Matrix Metalloproteinase 9 (MMP-9) Activity. Foods, 12(22), 4072. 
    Link: https://doi.org/10.3390/foods12224072
  3. Prakash, A., & Kumar, A. (2008). Effect of different doses of Manuka honey in experimentally induced inflammatory bowel disease in rats. Phytotherapy Research, 22(11), 1512–1519.
    Link: https://doi.org/10.1002/ptr.2523
  4. Brooks, P. (University of the Sunshine Coast). Manuka honey's anti-inflammatory gut benefits [Video]. Biosota Organics YouTube Channel.
    Link:     https://www.youtube.com/watch?v=J-ybCFSMtaU

Leave a comment

Please note, comments must be approved before they are published

This site is protected by hCaptcha and the hCaptcha Privacy Policy and Terms of Service apply.

Back to Resources